After two years together, numerous vacations and countless red carpet appearances, the Oscar-winning actor and the blond beauty have pulled the plug on their romance, E! News confirms.
So how did the longtime lovebirds go from head-scratching hookup to exes?
Let's take a look back at Clooney and Keibler's relationship:
August 2011: Just two months after the actor called it quits with girlfriend Elisabetta Canalis, the 52-year-old stud began getting cozy with Keibler. Rumors of their romance first began when Stacy joined George at his Lake Como villa in Italy, and the twosome quickly became one of the steamiest hookups of the summer.
September 2011: The gorgeous couple started heating up after Keibler accompanied Clooney to the Toronto Film Festival where eyewitnesses told E! News the pair looked "really happy" together.
October 2011: In signature Clooney form, the Oscar-winning actor took his new gal on a trip to Cabo San Lucas, Mexico, with a group of pals.
October 2011: The good-looking couple made their first public appearance together at the NYC premiere for Clooney's film The Descendants. The event marked the first time Keibler walked the carpet with her man.
October 2011: Less than one week later, the couple hit the carpet arm in arm at the Ides of March premiere in Paris, where they couldn't hide their affection for one another.
October 2011: While being presented with the Hollywood Actor Award at the Hollywood Film Awards, Clooney told a packed house he was a "lucky" guy. Of course, Keibler accompanied Clooney to the A-list soirée.
November 2011: The blond beauty meets Clooney's parents for the first time at the premiere for his flick The Descendants, seemingly suggesting things are getting serious for the picture-perfect pair.
January 2012: The WWE stunner accompanied her man on a number of red carpets during award season while Clooney's flick, The Descendants, continued to rake in accolades. "I like to play dress up and wear gowns and fancy jewelry," she told E! News at the Critics Choice Awards, where Clooney took home the award for Best Actor.
January 2012: The beautiful couple stunned at the Golden Globe Awards, where the actor took home the award for Best Actor in a Motion Picture Drama for The Descendants.
January 2012: The twosome stole the spotlight yet again at the SAG Awards, despite Clooney failing to nab the Best Actor honor.
February 2012: Clooney and Keibler were the It Couple at the Oscars where The Descendants won the Academy Award for Best Adapted Screenplay.
March 2012: The twosome is spotted in Mexico, indulging in a little post-awards-season R&R.
May 2012: Keibler is on hand to support her man at the actor's fundraiser for President Barck Obama's reelection campaign.
September 2012: Clooney shoots down tabloid reports claiming he and Keibler have gone their separate ways. "A story published by a London tabloid, The Sun, concerning George Clooney and Stacy Keibler is not true. Total fabrication designed to sell newspapers," the actor's rep told E! News.
October 2012: The couple is all smiles on the red carpet at the Argo premiere despite breakup reports.
October 2012: Keibler talks marriage and kids with E! News and candidly admits she's not looking to tie the knot, "That is not on my radar at all," she said. "I'm definitely the girl who doesn't talk about that kind of stuff. I'm not really interested in thinking about marriage or kids at all."
November 2012: The pair spend their second Thanksgiving in Cabo with BFFs Cindy Crawford and Rande Gerber.
January 2013: The stunning twosome costar in a short film for the actor's tequila brand, Calamigos.
January 2013: Clooney and Keibler rock the red carpet at the Golden Globes, where Agro nabbed the Best Picture honor.
February 2013: The flawless duo look oh-so-in love as they pose for pictures at the Oscars.
March 2013: The pair is once again plagued with breakup rumors, but a source told E! News the reports of a split were "not true" at the time.
March 2013: Clooney and Keibler are spotted out to dinner in Berlin—their last public appearance together.
July 2013: E! News confirms couple has split.