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Seth Rogen, Nancy Grace

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Twitter feud alert!

Seth Rogen had something not so nice to say to Nancy Grace earlier today after she went on an anti-marijuana Twitter rant.

Grace took to the social media site to share her thoughts about a recent Colorado shooting, writing, "Cops say daddy eats marijuana & goes crazy. He shoots his wife in the head while she pleads with 9-1-1 for help! #PotToBlame?"

"If pot makes you mellow and laid back, why does this guy allegedly turn berserk and gun down his wife? #PotToBlame?" the 54-year-old HLN host continued.

She added, "How many people must die before this stops?! #PotToBlame?"

That's when Rogen, an outspoken marijuana advocate, fired off. "@NancyGraceHLN you are a f--king dumbass," the Pineapple Express tweeted.

And believe it or not, Grace responded! "@Sethrogen hi seth! thx for watching!" she posted on her Twiiter.