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After starring as Claire Bennet for the show's 75 episodes, Hayden Panettiere went on to do Scream 4 before landing another starring role in the country music drama Nashville. She also famously dated her Heroes co-star, Milo Ventimiglia, during the show's run, but now the actress is a mother to Kaya, who she welcomed in 2014.
After playing Penettiere's dad in the iconic series, Jack Coleman acted in a slew of TV shows like The Vampire Diaries, as a (state) senator in The Office, Burn Notice and Scandal.
He also returned to the franchise in 2015 when he reprised his role for Heroes Reborn and Heroes Reborn: Dark Matters.
After playing Peter Petrelli, who had the ability to absorb other powers, Milo Ventimiglia could be found as the voice actor behind Wolverine in Wolverine and Marvel Anime before returning on-screen in roles in Mob City, The Whispers, Gotham and Chosen.
Of course, now he is most known for playing the perfect husband of Jack Pearson in This Is Us.
After portraying Hiro Nakamura, Masi Oka found a long-time home as a main character in Hawaii Five-0, which ran from 2010 to 2019.
While she was only in 13 episodes, Kristen Bell made an impression as Elle Bishop and we've only seen her star rise since with major roles in the Frozen films and as the lead of the critically-acclaimed shows Veronica Mars, House of Lies and The Good Place.
Zachary Quinto's star totally rose after Heroes with a compelling arc in American Horror Story and on the big-screen as Spock in the rebooted Star Trek franchise.
Most recently, you could catch Quinto in NOS4A2, where he plays an immortal villain who feeds off the souls of children, proving that the actor has plenty of range.
After playing Mohinder Suresh for a whopping 63 episodes, Sendhil Ramamurthy has gone on to delight us in all sorts of shows, such as on Covert Affairs, Beauty and the Beast and Mindy Kaling's latest show, Never Have I Ever.
Ramamurthy also reprised his role for Heroes Reborn in 2015.
After playing the telepathic Matt Parkman, Greg Grunberg appeared in episodes of Love Bites, Masters of Sex, The Client List and the terrifying Castle Rock.
James Kyson's career post-Ando Masahashi included guest star roles on shows like Hawaii Five-0, Justified and more, but also has impressively voiced in many of the biggest video games in the industry, like Grand Theft Auto 5 and Call of Duty: Advanced Warfare.
Adrian Pasdar has stayed booked and busy since Heroes end, voicing Marvel's Tony Stark in all sorts of projects like the Ultimate Spider-Man and Avengers Assembly animated series.
Pasdar also has appeared on screen, too, notably as Glenn Talbot in Agents of S.H.I.E.L.D. for four years.
The Final Destination actress was already a star when she came to Heroes, and has continued to work in TV after the series wrapped in shows like Legends, Pitch and 2019's The Rookie.
Ali Larter also starred in the Resident Evil sequels Resident Evil: Afterlife and Resident Evil: The Final Chapter as well.
Since Cristine Rose said goodbye to Heroes, we've seen her on How I Met Your Mother, Trial & Error, How to Get Away With Murder and even in an episode of the fantastically creepy HBO series Sharp Objects.