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Brie Larson has won big at the SAG Awards, after being named Best Actress in a movie for her work in Room.

It is the star's first SAG Award win.

Larson beat out Cate Blanchett (Carol), Helen Mirren (Woman in Gold), Saoirse Ronan (Brooklyn), and Sarah Silverman (I Smile Back).

"I feel like I was born questioning everything about reality, feeling lost and alone and always worried that I was deeply unlovable," said Larson, accepting her award.

She added: "And watching your movies... made me feel less alone and made me feel like that was a safe place to explore my creativity."

Larson thanked her costars, including the adorable Jacob Tremblay, who plays her onscreen son, who she called her "inspiration."

"Everything that is this movie is because of you," said Larson, as Tremblay smiled in the audience.

Larson won a Golden Globe for her work in the film and has also been nominated for an Academy Award for her role.

After learning of her Oscar nom, the actress said: "I thought, 'Holy s--t!' It's that, mixed with a total flat line."

"I didn't realize how strong my reaction would be," she continued. "My whole body was shaking. I started crying."

Room follows the journey of a young woman (Larson) who has been held captive in a shed for several years with her five-year-old son (Tremblay.)

Don't miss the Fashion Police Screen Actors Guild Awards special Monday at 8 p.m. only on E!