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A brand-new Machete Kills trailer is here!

In the latest video clip from the flick, some super-hot celeb ladies, including Lady Gaga, Sofia Vergara and Amber Heard, are bringing the heat!

President Charlie Sheen (billed as Carlos Estevez) calls on the help of Machete (Danny Trejo) to bring down an evil revolutionary (Mel Gibson) and his gang of bad guys.

Sofia Vergara, Machete Kills

Open Road Films

Included in that evil gang is a super-sexy Vergara, who uses her "double Ds" to shoot bullets from her breasts (yikes!). Meanwhile, Lady Gaga is armed and dangerous in a red dress. "Muy bien, indeed," the singer, who plays La Chameleon in the film, says in the trailer while grabbing her boobs.

Also bringing the heat is Machete's handler played by Heard, who wows in a red beauty pageant dress. The flick also stars beautiful gals Jessica Alba and Michelle Rodriguez, along with Antonio Banderas, Demian Bichir, Alexa Vega, Vanessa Hudgens and Cuba Gooding Jr.

Machete Kills hits theaters Oct. 11.