The 48-year-old actress, who calls Austin her adopted hometown, says she feels for those affected by the tragedy, which occurred in the small town just outside of Waco on Wednesday night.
"You don't know what to think of it," Bullock told E! News while promoting her new flick The Heat at CinemaCon in Las Vegas. "They don't know what to think of it. So you're just hoping and praying that everybody's OK, which, unfortunately, I think not everyone's going to be OK. It's a weird time right now."
The West, Texas explosion isn't the only recent incident that hits close to home for Sandra and her Heat coworkers. The film was shot in Boston, where the Boston Marathon bombings took place on Monday.
"The people of Boston were so wonderful," The Heat director Paul Feig tells us. "And we got to work with the law enforcement, the FBI, with their police, and these are just some of the best people I've ever met."
"If a town has to go through this, those are the people to be in charge of it," he continued. "They are just so wonderful and the people of Boston are so strong and just resilient. My heart goes out to them, because it's a blow that we all felt when it happened. But also I know they can get through this."
Feig says they're planning on holding a special screening of The Heat for the people of Boston. "The movie is really a love letter to Boston anyway and a lot of our cast are Bostonians," he said, adding, "I think they'd get a kick out of it."
Check out more from Bullock, Feig and Melissa McCarthy in our exclusive video clips!