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Five Trailer: Jennifer Aniston and Demi Moore Direct the Saddest TV Movie You'll See This Year

Lifetime is counting on making you cry again.

From directors Jennifer Aniston, Demi Moore, Alicia Keys, Penelope Spheeris and Patty Jenkins comes Five, which combines five separate-yet-interconnected tales of lives affected by cancer, each one named after the central female in each segment.

And good lord, did these ladies go all out with the tears, the heartbreaking glances, the tender moments, the life lessons, and...the stellar cast!

READ: Jennifer Aniston Lends Big Heart—and Director's Eye—to Breast Cancer Movie

Jeanne Tripplehorn's cancer-stricken oncologist is the common thread running through all five tales, the one who calmly yet sympathetically has to deliver far more bad news than good to her patients, among them Patricia Clarkson and Rosario Dawson.

Josh Holloway, Ginnifer Goodwin, Jennifer Morrison, Lyndsy Fonseca, Tracee Ellis Ross, Tony Shalhoub, Annie Potts, Taylor Kinney, Bob Newhart, Kathy Najimy, Jeffrey Tambor and Jenifer Lewis fill out the ensemble.

The movie, which premieres Oct. 10 on Lifetime, marks Aniston, Moore and Keys' feature directing debuts.

"We were intrigued by the challenge of creating short stories that would defy audiences' expectation of the subject," Aniston, who helmed the segment titled "Mia," told Glamour. (Moore directed "Charlotte," Keys made "Lili," Spheeris presided over "Cheyenne" and Jenkins over "Pearl.") "We wanted to balance the drama with humor and irreverence because that's what's helped our friends who've faced this get through their treatment."

Well, Lifetime didn't want to balance the trailer with humor and irreverence, but we'll take Jen's word for it that it's in there and tune in for the whole package.

WATCH: Jen, Demi and Alicia take Five

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