Well, if she can't play herself...
Filming starts soon, and then comes the long and nail-biting process of waiting to see if the network picks it up.
"We start in a couple weeks," Prepon told E! News Thursday at Kari Feinstein's 2011 Academy Awards Style Lounge. "I hope NBC gets behind it. There's a lot of buzz. It's different and edgy."
Pickup worries aside, Prepon is willing and able to throw herself into the role of Chelsea, even if she wasn't exactly a fan of hers from the beginning.
"I haven't read [her books]," Prepon tells us. "But I've seen her a lot and it's going to be awesome. I am just starting to immerse myself in the Chelsea Handler of it all. She's an amazing woman."
Prepon adds that she'll be a quick study of the Are You There, Vodka? It's Me, Chelsea author—Including her drink of choice.
"I'm from Jersey," says Prepon. "Chelsea and I are similar, so it's perfect we play sisters. It's funny, because her vodka is my favorite vodka too," says Prepon. "We both drink the same thing!"