Christina Applegate Gets Standing Ovation at Emmys 2023 Amid Multiple Sclerosis Battle

Christina Applegate attended the Emmys 2023 amid her battle with multiple sclerosis, celebrating her Outstanding Lead Actress in a Comedy Series nomination for her work in Dead To Me.

By Gabrielle Chung Jan 16, 2024 1:19 AMTags
Watch: 2023 Emmys Recap: Must-See Moments & Emotional Wins!

Christina Applegate is taking in the view from the top of the Emmys 2023 stage.

The Dead to Me star—who is battling multiple sclerosis—attended the Jan. 15 award show amid her health journey, stepping out at Los Angeles' Peacock Theater to present the category for Outstanding Supporting Actress in a Comedy Series (which ultimately went to Ayo Edebiri).

In addition to rocking a red velvet gown by Christian Siriano, Applegate also accessorized with a special cane—which she started using after being diagnosed with MS in 2021. As she walked out on stage, she received a standing ovation from TV's biggest stars in the crowd. Applegate turned toward host Anthony Anderson in tears, saying, "Thank you so much. Oh my god."

"You're totally shaming me with disability by standing up," she joked to the crowd. "It's fine."

The 52-year-old is nominated for Outstanding Lead Actress in a Comedy Series at this year's ceremony for her portrayal of Jen Harding in the third and final season of Dead to Me. Her fellow nominees include Wednesday's Jenna Ortega, Poker Face's Natasha LyonneAbbott Elementary's Quinta Brunson and The Marvelous Mrs. Maisel's Rachel Brosnahan.

The nod is especially significant given the Samantha Who? alum previously expressed doubts in ever being nominated for her work again, hinting last year's SAG Awards would be "my last awards show as an actor probably."

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A Look at Christina Applegate's Unforgettable Roles

"Right now, I couldn't imagine getting up at 5 a.m. and spending 12 to 14 hours on a set," she told the Los Angeles Times in February, alluding to retiring her decades-long acting career amid her MS battle. "I don't have that in me at this moment."

Applegate continued, "I don't like seeing myself struggling. I gained 40 pounds because of inactivity and medications, and I didn't look like myself, and I didn't feel like myself."

VALERIE MACON/AFP via Getty Images

However, the Anchorman actress noted that she may pivot to producing and "doing a s--t ton of voice-overs to make some cash to make sure that my daughter's fed and we're homed." 

Applegate, who shares 12-year-old Sadie Grace with husband Martyn LeNoble, added of what may be her final onscreen role, "At some point I was able to distance myself from my own ego, and realize what a beautiful piece of television it was. All the scenes I wasn't in were so much fun to see and experience for the very first time."

To see Applegate and more celebs at the Emmys Awards, keep reading.

Suki Waterhouse

in Valentino and Tiffany 7 Co. jewelry. 

Jessica Chastain

in custom Gucci & Reza jewelry.

Jeremy Allen White

in custom Giorgio Armani and a Vacheron Constantin watch.

Taraji P. Henson

in custom Atelier Versace, Alexandre Birman shoes and Simon G jewelry.

Selena Gomez

in Oscar de la Renta and Tiffany & Co. jewelry.

Camila Morrone

FIJI Water and JUSTIN Vineyards & Winery returned as the Official Water and Official Wine Partners at the Emmys.

James Marsden

FIJI Water kept stars hydrated with the company's iconic bottles.

Meghann Fahy

in custom Armani Privé & Bulgari jewelry.

Evan Peters

in Dior Men.

Bella Ramsey

in Prada.

James Marsden

in Canali. 

Bill Hader

in Dior Men.

Abby Elliott

in Alexander McQueen.

Jason Sudekis

Priscilla Presley

Jessica Williams

in custom Rodarte.

Kathryn Hahn

in Christian Dior.

Calista Flockhart

in Armani Privé.

Leo Woodall

Lauren Ambrose

Mychal Bella Bowman

Zawe Ashton

Tracee Ellis Ross

in Sportmax and Pomellato jewelry.

Natasha Lyonne

in Schiaparelli.

Kaitlin Olson

in Monse.

Lizzy Caplan

in vintage Yohji Yamamoto and Fred Leighton jewelry.

Kumail Nanjiani

in Brunello Cucinelli and IWC Schaffhausen watch.

J. Smith-Cameron

in Christian Siriano.

Ellen Pompeo

in Monique Lhuillier and REZA jewelry.

Christina Ricci

in Saint Laurent.

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View More Photos From Emmys 2023: Celebrity Red Carpet Fashion
For a full recap of the 75th Emmy Awards, check out E! Online's Emmys homepage here.