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Renée Zellweger is standing up.

And so are Rob Lowe, Josh Groban, Michael Strahan and Mandy Moore.

These stars and more are featured in a new Stand Up To Cancer public service campaign encouraging people to do what they can in the fight against cancer.

In addition to the launch of the new spots, Stand Up to Cancer has partnered with E! Online's parent company, Comcast, to offer its 18 million cable customers music videos from on-demand from superstars like Justin Timberlake, Beyoncé, Mariah Carey and Lady Gaga that will also offer information on how to donate to the cancer organization.

Sounds like the perfect way to give back this holiday season.