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Khloé Kardashian Takes Over Chelsea Lately: Pokes Fun at Kris Jenner and Kim Kardashian, Talks Oprah and Much More!

Look out folks, because today Khloé Kardashian is in charge.

Khloé stepped in as host for tonight's Chelsea Lately, looking fabulous in a skintight brown dress. Kris Jenner was also backstage, and Khloé didn't waste any time getting in a quick jab at her mom and sister Kim Kardashian.

"My mom basically tags around with Kim, follows her around, dresses like Kim," Khloé laughed. "I'm her favorite today, but normally it's Kim everyday, all day, erryday."

VIDEOS: Watch Cameron Diaz give Chelsea tips on "feminine" care

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Major topics that Khloé covered included Justin Bieber partying with his dad, former president Bill Clinton taking photos with hookers and Oprah Winfrey's new documentary series about Lindsay Lohan.

Khloe expressed her excitement to watch the upcoming series and pointed out, "If Oprah curses, s--- just got real."

Tonight's guest star was Cupcake Wars host and world-famous magician Justin Willman, who reminisced about the time he played a prank on Khloé.

Justin also joked about his huge gay following in Iowa, before entertaining the crowd with a card trick and by swallowing a balloon sword animal.

"This could go so many wrong ways," Khloé said to the audience.

Tune-in to the brand-new Chelsea Lately with guest host Khloé Kardashian tonight at 11/10c only on E!

PHOTOS: Check out Khloe Kardashian's best looks

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