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Details surrounding Alexis Arquette's shocking death have emerged.

The 47-year-old transgender actress—who has acted in more than 50 films spanning her decades-long career, notably in Last Exit to Brooklyn and as a Boy George impersonator in The Wedding Singer—died from a heart attack, E! News confirms.

We've obtained Arquette's death certificate, which lists the heart attack as the immediate cause of death, and also reveals that the star suffered from a bacterial infection of the heart three weeks prior to her cardiac arrest on Sept. 11. The certificate also states that Arquette was living with HIV for 29 years, which was noted as an underlying cause of death.

Alexis' brother Richmond Arquette confirmed the news of his sibling's death on his Facebook page earlier this month, writing, "Our brother Robert, who became our brother Alexis, who became our sister Alexis, passed this morning September 11 at 12:32 a.m. He was surrounded by all of his brothers and sisters, and one of his nieces and several other loved ones...As per his wishes, we cheered at the moment that he transitioned to another dimension."

Hours after news broke of her passing, brother David Arquette headed to Twitter to pay tribute to Alexis, and also express gratitude for the love he'd received from fans. "Thank you all for your love and kind words about Alexis," he shared on social media. "My hero for eternity."

Soon after, Courteney Cox, who was married to David Arquette from 1999 to 2013, expressed her condolences to the family with a heartfelt message online. "My heart goes out to anyone who was lucky enough to know Alexis," she wrote. "We will love and miss you forever."

Sister Patricia Arquette later tweeted, "To My first best friend - Cosmic Dancer. Breaking through the veil singing StarMan." 

The family asks that in lieu of flowers or gifts, fans can send donations to organizations that support the LGBTQ community in honor of Alexis.