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Seth Rogen, Lauren Miller

Dimitrios Kambouris/WireImage

Seth Rogen sure knows how to work a room.

The funnyman and his wife, Lauren Miller, helped raise more than $400,000 to fight Alzheimer's at the second annual Hilarity for Charity event in Los Angeles Thursday, according to The Hollywood Reporter.

The fight to cure Alzheimer's is a cause close to the couple's hearts, given that Miller's mother was diagnosed with the disease at 55, and both of her grandparents have it as well.

"Bringing Alzheimer's into the limelight is what we're trying to do," Rogen told the mag. 

"Young people, unless they've been touched by the disease, don't really understand Alzheimer's and how it's growing," Miller added. "We want to focus on young people and their awareness of Alzheimer's." 

Celebs like Nick Kroll and Samuel L. Jackson were also on hand for the event, with the Django Unchained star revealing that his mother died in November from the disease and many other members of his family had passed away from Alzheimer's as well.

"So I have the potential to be one of the people you're raising money for," Jackson reportedly told the crowd. "It's a pretty devastating disease...but [those who have it] can also be very funny."

Speaking of funny, Kevin Hart brought on the laughs at the event, joking about his recent DUI bust

"Stop f--king judging because I got a DUI," Hart told the audience. "Reese's was much worse than mine. She talked back to the cop. I said ‘Yes, sir, boss.' I stumbled when I said it. Reese was like ‘Do you know who the f--k I am?' I would never say that. That's followed by a billy club."

Meanwhile, Judd Apatow announced via email (read by Rogen) that he would match up to $15,000 in donations, which prompted Numb3rs alum David Krumholtz to make a donation of $15,000!

Celebrity do-gooders indeed.