Popping up on NBC's Today for the first time since the demise of her short-lived OWN variety show, the outspoken comedian couldn't resist offering up her verdict on the casting of the Mean Girls actress to play the late Hollywood icon in a Lifetime TV movie.
Needless to say, it wasn't good.
"I feel very sorry for her," said O'Donnell. "I think she needs a lot of help. She needs a lot of time away."
The quip alluded to all the legal problems that have been plaguing Lohan the last few years (see her DUI and necklace-jacking case), which have landed the starlet in jail and up until last month on probation.
But when asked by Matt Lauer whether it's a "good idea" for LiLo to do this movie, which chronicles the Cleopatra star's love affair with husband Richard Burton, Rosie was adamantly against it.
"No. Because she's had a lot of trouble doing every single movie, including [Saturday Night Live]. She was out and not at rehearsal and I think she's not in a place to work."
When fellow panelist Donny Deutch chimed in with a thumbs-up, comparing Lindsay to "this generation's Elizabeth Taylor," O'Donnell didn't hold back.
"You're out of your mind!" she replied. "You're a crackhead...The last thing she did good she was 16!"
The former Queen of Nice elaborated further, "I don't think she's right for the role, and I don't think she's capable at this point of doing what's needed to portray that character. I think the interest level in her has waned significantly."
Guess Rosie won't be tuning in.
And how did Team Lindsay take all this?
Reacting to the tirade, Lohan's publicist told E! News exclusively: "I think Rosie should focus on her own career and stop worrying about everyone else's."
It is on!
—Additional reporting by Katie Rhames