While audiences were just bummed to hear the news, network execs have been scrambling to fill the inevitable void on the daytime talk-show circuit.
And sources tell E! News that Rosie O'Donnell is mulling a return to daytime TV once Winfrey signs off.
Since leaving The View in a feud of glory in May 2007, O'Donnell hasn't had much success on the small screen, other than some good guest spots on Curb Your Enthusiasm, Nip/Tuck and Drop Dead Diva. She joined the Sirius XM family last year, launching the daily Rosie Radio show, which she hosts from a custom-built home studio in New York.
Back when she wasn't such a polarizing figure, The Rosie O'Donnell Show won 25 Daytime Emmy Awards, including Outstanding Talk Show every year between 1998 and 2002.
The O'Donnell comeback possibility was first reported by Showbiz411.
This whole thing just reminds us that Oprah's going off the air soon. Look back at some of her best moments in our gallery.