While audiences were just bummed to hear the news, network execs have been scrambling to fill the inevitable void on the daytime talk-show circuit.
And sources tell E! News that Rosie O'Donnell is mulling a return to daytime TV once Winfrey signs off.
Since leaving The View in a feud of glory in May 2007, O'Donnell hasn't had much success on the small screen, other than some good guest spots on Curb Your Enthusiasm, Nip/Tuck and Drop Dead Diva. She joined the Sirius XM family last year, launching the daily Rosie Radio show, which she hosts from a custom-built home studio in New York.
Back when she wasn't such a polarizing figure, The Rosie O'Donnell Show won 25 Daytime Emmy Awards, including Outstanding Talk Show every year between 1998 and 2002.
The O'Donnell comeback possibility was first reported by Showbiz411.