Simu Liu is starting the night with a jab or two.
The 2024 People Choice Awards host couldn't help but poke fun at some of Hollywood's most popular cosmetic treatments during the Feb. 18 event.
"Welcome to the 49th annual People's Choice Awards," Simu explained launching into his opening monologue, "that's right, the show is almost 50 years old, but it is Hollywood."
"So, with a little Botox, some light filler and a couple months on Ozempic, it won't look a day over 31," the Barbie star continued. "I guarantee it."
And the actor is just the latest star to weigh in on the drug, originally intended to treat type 2 diabetes.
Most recently, Kelly Osbourne recently said that she thinks criticism of the drug comes from a place of jealousy.
"I think it's amazing," she told E! News while at Dolly Parton's Pet Gala red carpet Jan. 30."There are a million ways to lose weight, why not do it through something that isn't as boring as working out?"
Others, however, have been more hesitant about its weight loss benefits.
"I think it's very important we understand certain medications are made for certain people," Raven-Symoné told E! News in July, "and to not take that away just for glamazon purposes."
She continued, "Do what you gotta do, just make sure you save the medication for the people who actually need it."
But needless to say, Ozempic will continue to be a subject of debate for stars in Hollywood.
Keep reading to see which celebs made their way to the People's Choice Awards.
Donald Faison
Glen Powell
In Brioni.
Abigail Spencer
In Sophia Webster platforms.
Joe Manganiello
Jennifer Aniston
Adam Sandler
Megan Fox
In Vivienne Westwood.
Billie Eilish
Brianne Howey
In Silvia Tcherassi.
Alix Earle
In Tony Ward.
Bobbi Althoff
In Mônot.
Tom Hiddleston
Jake Lacy
Harry Jowsey
In Dior.
Camilla Luddington
Hannah Godwin
In Milla Nova Couture.
Kim Raver
In Jason Wu.
Jason & Brett Oppenheim
Kane Brown
Dolores Catania
In a CD Greene and Sam Edelman heels.
Caterina Scorsone
Chris Carmack
Cathy Kelley
Olivia Ponton
In Alexander McQueen.
Mary Fitzgerald
In a MaisonMet gown, Le Silla heels and Simone Jewels earrings.
JB Smoove
Jeannie Mai
In Lena Berisha.
Shameik Moore
Katie Douglas
Whitney Cummings