Brandi Glanville, Lisa Vanderpump

Joe Pugliese/Bravo

It seems as if there's some trouble brewing in Beverly Hills.

Brandi Glanville and Lisa Vanderpump—who famously became BFFs when Glanville joined the Real Housewives of Beverly Hills—have hit a rough patch in their famous friendship and have apparently had a falling out.

A source tells E! News the onetime tight-knit twosome butted heads while filming the upcoming season, revealing something "went down while they were all in Puerto Rico," although the insider could not disclose any specific details.

Brandi herself confirmed there's currently some beef between the former besties, tweeting back to a fan who asked if the ladies were no longer friends.

"I will always love her but sometimes friends have hic-ups," the reality star wrote.

But turns out, the Drinking and Tweeting author isn't the only Housewife who's in hot water with Mrs. Vanderpump.

The source also added Lisa is "not getting along" with any of her castmates after the crew's trip to the Caribbean island.

Filming for season four of the reality series has reportedly been completed, and as E! News previously reported, two new Housewives, Carlton Gebbia and Joyce Giraud, are joining the series

In June, sources close to production told E! News Giraud was already making waves on the show, instantly befriended Kyle and Kim Richards while making enemies of Glanville and Vanderpump.

But when there's wine and catfights involved, we all know how quickly that can change.

Are you excited for season four of the RHOBH? Tell us in the comments!

PHOTOS: Before they were Housewives!

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