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One of the Brat Pack's biggest stars, Lowe starred in St. Elmo's Fire, The Outsiders, and About Last Night, which also starred Demi Moore, going on to star in hit comedies Wayne's World, Austin Powers and Tommy Boy in the '90s.
In 1999, Lowe starred on The West Wing, one of TV's most critically acclaimed series, and later starred on ABC's Brothers & Sisters before joining the cast of NBC's beloved sitcom Parks & Recreation. He then starred on Code Black and currently stars on Fox's 9-1-1: Lone Star and recently starred in a Netflix Christmas movie, Holiday in the Wild, opposite Kristin Davis.
Lowe has been married to makeup artist Sheryl Berkoff since 1991 after being set up on a blind date in 1983, and have two sons together, Matthew, 27, and John, 25. In 2017, Lowe and his two sons starred in The Lowe Files together, a paranormal reality series.
The 56-year-old has written two best-selling books, his 2011 memoir Stories I Only Tell My Friends, and 2014's Love Life. In his memoir, Lowe opened up about his struggles with addiction, going to rehab in 1990 following a sex tape scandal in 1988.
"It's one of the reasons I got sober. I woke up one day and was like, 'what am I doing with my life?,'" Lowe later said. In May 2020, Lowe celebrated 30 years of sobriety.