ERs 25th anniversary - cast

NBCU Photo Bank

Television was changed 25 years ago. On this day, September 19, in 1994, ER premiered on NBC. The medical drama, which lasted for an impressive 15 seasons, helped launch the careers of numerous stars, like George Clooney and Julianna Margulies, and redefine the careers of others, like Maura Tierney and John Stamos.

ER was a TV titan, entertaining—and educating—millions for almost two decades. Over the years, the cast came and went in a variety of ways, from happy departures to tragic deaths, but ER endured. Over 15 years, ER was nominated for 124 Emmys, winning 22.

"It's really just an incredible confluence of good luck and wonderful collaborative efforts," casting director John Levey told The Hollywood Reporter. "We went through so many different showrunners, although John [Wells] was there all the time. But [there were] people who ran the directors' element or who were instrumental in the writers room, and then of course, the cast changed and evolved. We didn't do what lots of other franchises did, where you did a whole new version — ER Toledo or ER Boston — we just kept rejuvenating ER Chicago with new and interesting people. The medicine stayed the star, but the characters were new and different as the years went on. So it remained incredibly exciting. And it was a fantastic example of what excellence and collaboration and community can produce. John runs a fantastic ship. And it was fun and exciting from day one through day 2 million."

As we celebrate the 331 hours of TV that entertained us for 15 years starting in 1994, take a look at what the iconic cast, which had more than 25 series regulars over the years, is up to now.

Anthony Edwards, ER: Where Are They Now

NBCU Photo Bank; Jim Spellman/Getty Images

George Clooney, ER: Where Are They Now

NBCU Photo Bank; Doug Peters/PA Images/

Sherry Stringfield, ER: Where Are They Now

NBCU Photo Bank; Jonathan Leibson/WireImage

Noah Wyle, ER: Where Are They Now

NBCU Photo Bank; Ken McKay/ITV/Shutterstock

ER: Where Are They Now, Julianna Margulies

NBC/ Michael Loccisano/Getty Images

ER: Where Are They Now, Eriq La Salle

NBC/ Timothy Hiatt/Getty Images

ER: Where Are They Now, Gloria Reuben

NBC/ Michael Loccisano/Getty Images

ER, Kerry Weaver, Laura Innes

Chris Haston/NBC/NBCU Photo Bank, Leon Bennett/WireImage

ER, Anna Del Amico, Maria Bello

Chris Haston/NBCU Photo Bank, Leon Bennett/WireImage

ER, Elizabeth Corday, Alex Kingston

Paul Drinkwater/NBCU Photo Bank, Jason LaVeris/FilmMagic

ER, Lucy Knight, Kellie Martin

NBC/Tara Ziemba/Getty Images

ER, Dave Malucci, Paul McCrane

Noel Vasquez/Getty Images

ER, Luka Kovac, Goran Visnjic

NBC/Phillip Faraone/Getty Images

ER, Michael Michele

NBC/Jason Bahr/Getty Images

ER, Dave Malucci, Erik Palladino

NBC/Kevin Winter/Getty Images

ER, Jing-Mei “Deb” Ming-Na Wen

NBC/Frazer Harrison/Getty Images

Maura Tierney, Abby Lockhart, ER

Mitchell Haaseth/NBCU Photo Bank, Kevin Winter/Getty Images

ER, Michael Gallant, Sharif Atkins

Gabriel Olsen/Getty Images

ER, Greg Pratt, Mekhi Phifer

Dimitrios Kambouris/Getty Images

ER, Neela Rasgotra, Parminder Nagra

Matt Winkelmeyer/Getty Images for Netflix NBC

ER, Sam Taggart, Linda Cardellini

Mike Coppola/FilmMagic NBC

ER, Ray Barnett, Shane West

Monica Schipper/WireImage NBC

ER, Archie Morris, Scott Grimes

Gary Gershoff/WireImage NBC

ER, Tony Gates, John Stamos

David Livingston/Getty Images) NBC

ER, Simon Brenner, David Lyons

Greg Doherty/Patrick McMullan via Getty Images) NBC

ER, Catherine Banfield, Angela Bassett

David Crotty/Patrick McMullan via Getty Images NBC

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