The Trainwreck actress slammed celebrities for not being honest about using the type 2 diabetes medication, which has become the latest weight loss trend in Hollywood.
"Everyone and their mom is gonna try it. Everyone has been lying saying, 'Oh, smaller portions,'" she said on Watch What Happens Live with Andy Cohen on June 8. "Like, shut the f--k up. You are on Ozempic or one of those things, or you got work done. Just stop."
In fact, Amy said she's never been one to shy away from her medical procedures. "Be real with the people," the comedian added. "When I got lipo, I said I got lipo."
The 42-year-old admitted she too "immediately invested" in Ozempic about a year ago; however, it was not "livable" and hindered her abilities to spend time with her and husband Chris Fischer's 4-year-old son, Gene.
"I was one of those people that felt so sick and couldn't play with my son," she recalled, "I was so skinny, and he's throwing a ball at me and [I couldn't]."
And Amy isn't the only star who has been open about taking Ozempic. Last month, Golnesa "GG" Gharachedaghi got candid on using injection shots of Semaglutide—the generic version of the weight-loss drug.
"I don't see a reason to hide being on a weight loss [medication] or a cosmetic procedure," Golnesa told Entertainment Tonight May 18, "just talk about it because there's so many people out there who want to do the same thing or they want to learn about what you did."
A rep for the pharmaceutical company Novo Nordisk previously told E! News in a statement that Ozempic is "not approved for chronic weight management," noting that the medication is intended to treat type 2 diabetes, improve blood sugar and reduce the risk of major cardiovascular events for adults with the condition.