Why She Will Be Nominated: She has a solid history of getting wins for guest roles (Friends) and nods for lead roles (Samantha Who?) in her comedies. Who doesn't love Christina Applegate?!
Why She Won't: The same reason her costar Will Arnett might miss a nomination: Up All Night took too much time to find a rhythm, and the voters might want to see what its second season looks like before handing out Emmy votes to them.