The Kentucky native plays Paul Kemp, a freelance journalist who goes to Puerto Rico for a job in the 1960s. While on assignment he discovers it's not so easy to balance island culture and the expatriates who live there.
After being set free, vampire Barnabas Collins (Depp) returns to his home to find that his dysfunctional descendants are in need of his help and protection.
Of course Depp has done a Western! In The Lone Ranger, Native American warrior Tonto (Depp) tells the untold stories that made man of the law John Reid (Armie Hammer) into the legend of justice known as The Lone Ranger.
In another musical, Depp plays the Wolf, one of the many Brothers Grimm characters seen throughout this fairy tale film that follows a baker and his wife on a journey to find magical items that will break the curse an evil witch has placed on them.
Charlie Mortdecai (Depp) must juggle angry Russians, the British MI5 and an international terrorist while trying to recover a stolen painting that could have a code that leads to lost gold.
This J.K. Rowling film, focuses on the adventures of writer Newt Scamander (Eddie Redmayne) in New York City's secret community of witches and wizards. It takes place 70 years before Harry Potter reads his book at Hogwarts. Depp made a cameo in the film playing dark wizard Gellert Grindelwald.
The final Pirates film in the franchise has Jack Sparrow (Depp) and Will Turner's (Bloom) son Henry (Brenton Thwaites) searching for the trident of Poseidon. At the same time they are being pursued by an undead sea captain and his deadly crew.
Based on the book by Agatha Christie, Murder on the Orient Express is a mystery about the murder of Edward Ratchett (Depp), an art thief and murderer himself, on a train that has 12 suspects and one detective.
In 2018, Depp's character, the evil Grindelwald, makes his real debut in the Fantastic Beasts world. In the film, Albus Dumbledore (Jude Law) and his former student Newt Scamander (Redmayne) team up to try and stop Grindelwald's plans of raising pure-blood wizards to rule over all the non-magical people.