The singers have split up after nearly six years of marriage, E! News confirms.
"Mandy Moore and Ryan Adams have mutually decided to end their marriage of almost 6 years," reps for the duo said in a joint statement. "It is a respectful, amicable parting of ways and both Mandy and Ryan are asking for media to respect their privacy at this time."
Moore, 30, and Adams, 40, do not have any children together. They tied the knot on March 10, 2009, in Savannah, Ga.