Say it ain't so, folks!
Distance was reportedly a factor in the decision. The 52-year-old actress lives in New York City, while the 62-year-old rocker currently resides in Indiana.
The pair quietly became an item in 2010 after Mellencamp split from his wife, Elaine Irwin, after 18 years of marriage. Ryan was previously married to The Rookie actor Dennis Quaid.
Although they both led very private lives, the twosome was spotted spending time together on Martha's Vineyard. They also were seen enjoying coffee and running errands in New York's SoHo neighborhood.
Today, both Mellencamp and Ryan are focused on their upcoming projects.
The rocker has plans to release his 22nd album, Plain Spoken, in November. At the same time, Ryan is working behind the scenes as a director of Ithaca, a World War ll drama starring Tom Hanks.
Closer Weekly was first to report the news.