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In honor of TV personality and disc jockey Ryan Seacrest, an all-new special on E! will be celebrating some of his biggest on-air moments from the past 10 years!

Ryan has been the host of KIIS-FM's morning radio show since 2004, and has interviewed the likes of everyone from Justin Bieber to Miley Cyrus to first lady Michelle Obama.

Ryan Seacrest Special

Relive all of your favorite moments with Ryan by revisiting some of his very first interviews on the show, celebrity pranks, as well as some of the biggest scandals that Hollywood has ever seen.

From the infamous Kanye West and Taylor Swift Grammys moment to Chris Brown and Rihanna, Ryan has managaed to successfully get the real stories from some of Tinseltown's biggest names.

Tune-in to Best Moments: On Air with Ryan Seacrest on Wednesday, April 23 at 8/7c only on E!