In a joint statement, the couple said, "We will always love each other and be best friends; however, we have mutually decided to separate at this time."
The sad news comes on the heels of one of the busiest times in both Thicke and Patton's careers.
Thicke is currently on the Blurred Lines North America Tour, which is scheduled to last until the end of March.
Meanwhile, the 38-year-old actress is hard at work on her latest film project, Warcraft, in Vancouver.
The stunner stars alongside Ben Foster and Dominic Cooper in the action-packed film based on the popular computer game.
Patton did manage to squeeze in some much needed pampering earlier this month.
E! News has learned that she stopped by the Éminence Organics office and received a VIP treatment with the president of the company. Sounds like a lovely way to beat the blues!
And while Patton is spending the bulk of her time shooting for the upcoming flick, Thicke has been on full-time daddy duty.
He was spotted taking their 3-year-old son, Julian, to Disneyland just one day before it was announced that he was splitting from Patton.
But it appears that Patton is going to step back into the spotlight this coming Saturday, where she's currently slated to present at the Independent Spirit Awards.
She and Octavia Spencer announced the nominations for this year's awards show back in November.