Burton and Taylor, Cruise and Kidman, Pitt and Jolie…Wilde and Sudeikis?
The real-life couple will play Barrett and George, star-crossed lovers battling to keep their romance afloat in face of their various phobias: She suffers from high anxiety while he's an agoraphobe who freaks out just being in wide open spaces.
Sudeikis' fellow Saturday Night Live castmember Fred Armisen is aboard as George's best friend while Brie Larson will play Barrett's sister.
The script for Relanxious was written by newcomer Christopher Storer, who's making his directing debut on the project.
The funnyman has had a banner year as far as his burgeoning movie career, having starred in last summer's comedy hit Horrible Bosses and Hall Pass, while the erstwhile House star has become fanboys' favorite leading lady, having appeared in the blockbusters Tron: Legacy and Cowboys and Aliens.