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The stars came out tonight with hopes of brightening the way for years to come.
Halle Berry, Jennifer Garner, Jennifer Aniston, Salma Hayek, Ellen DeGeneres, Keanu Reeves, Billy Crystal, Scarlett Johansson, Julia Louis-Dreyfuss, Casey Affleck, America Ferrera, Fran Drescher, Forest Whitaker, John Krasinski, Christina Applegate, Josh Brolin and Masi Oka are just some of the A-listers who participated Friday in the Stand Up to Cancer telethon, benefiting cancer research, at Hollywood's Kodak Theatre.
Meryl Streep, Charlize Theron, the stars of Lost, Lance Armstrong, Tina Fey and some fellow 30 Rockers, Carson Daly and Tom Green also spoke up via video.
But despite a roster of names that wouldn't have seemed out of place at the Oscars, it was sobering to see how many of the event's participants' lives have been affected by cancer, including Applegate, who after being diagnosed with breast cancer this year underwent a preventative double mastectomy, Katie Couric, whose husband, Jay Monahan, died of colon cancer in 1998.