Harrison Ford, Calista Flockhart

Dominique Charriau/WireImage.com

After dusting off his fedora for Indiana Jones and the Kingdom of the Crystal Skull, Harrison Ford is ready to trade in his bullwhip for a microscope.

The 65-year-old star will top the marquee for Crowley, a drama inspired by the true story of John and Aileen Crowley, whose two children successfully battled an extremely rare genetic disorder. Ford will play a maverick scientist who comes to the family's aid.

The actor will also serve as an executive producer for CBS Films. Tom Vaughn (What Happens in Vegas) is in talks to direct.

Crowley marks CBS Films' first feature in a slate that will see four to six pictures, budgeted at up to $50 million apiece, released each year.

Ford is next set to costar with Sean Penn and Ashley Judd in Crossing Over, an immigration drama with multiple characters and narratives in the vein of Traffic and Crash.

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