The comedian and talk show host shows up several times, first in season five when, after Larry has upset the gay community, she informs him that she has happily vouched for him. "Lesbians love you," she reassures him.
In season seven she joins Larry and Jeff for lunch, telling Larry it might be a little "mean and insensitive" to deliver really bad news directly after sunshiny news. Then a vicious battle for the check between Larry and Rosie ensues, one of many tug-of-wars over a restaurant bill that has ensued over the years.
The next season she runs into him at an art gallery, where they find out they've both met and swooned over the same woman that night. Needless to say, they can't agree on who should be the one to "back away."