"Sandra and Andy are the perfect choices to host this world-class event," said Paul Telegdy and George Cheeks, the co-chairmen of NBC Entertainment, in a statement. "They bring wit, charm, and style to a room filled with the very best of film and television. It's sure to be another unforgettable, fun-filled night."
Samberg is a two-time Golden Globe Award winner for Brooklyn Nine-Nine and Oh won a Golden Globe in 2006 for her performance on Grey's Anatomy.
Nominations across all film and television categories will be announced Dec. 6.