Desperate Housewives - 2004

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Oh, Wisteria Lane.

Never in the history of television has one cul-de-sac been the epicenter for more death and destruction, calamity and comedy. We're talking, of course, about the iconic suburban setting of ABC's beloved and long-running dramedy Desperate Housewives.

Premiering in the fall of 2004, the show created by former Golden Girls writer Marc Cherry and starring Teri Hatcher, Felicity Huffman, Marcia Cross, Eva Longoria and Nicollette Sheridan, was one of three that season, along with Lost and Grey's Anatomy, that helped turn the struggling Alphabet network's fortunes around while giving fans more sexy hijinks and outlandish mysteries to obsess over than they quite knew what to do with. 

Over the course of the show's eight seasons, fans watched as one disaster after the next befell the supremely unlucky residents of the outwardly quaint neighborhood while gossip about on-set behavior provided plenty of fodder for tabloids. And while the show certainly seemed to be running on fumes by the time it signed off in the spring of 2012, there's no denying just what a pivotal role it played in this recent golden age of television.

In honor of Longoria's 45th birthday on Sunday, March 15, we thought we'd check in with everyone who was ever a part of the show's sprawling main cast and see what they've been up to since they said goodbye to Wisteria Lane nearly a decade ago.

Teri Hatcher - Desperate Housewives then and now

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Felicity Huffman - Desperate Housewives then and now

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Eva Longoria - Desperate Housewives then and now

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Marcia Cross - Desperate Housewives then and now

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Nicolette Sheridan - Desperate Housewives then and now

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Steven Culp - Desperate Housewives then and now

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Ricardo Antonio Chavira - Desperate Housewives then and now

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James Denton - Desperate Housewives then and now

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Doug Savant - Desperate Housewives then and now

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Brenda Strong - Desperate Housewives then and now

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Richard Burgi - Desperate Housewives then and now

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Dana Delany - Desperate Housewives then and now

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Andrea Bowen - Desperate Housewives then and now

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Vanessa Williams - Desperate Housewives then and now

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Jesse Metcalfe - Desperate Housewives then and now

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Mark Moses - Desperate Housewives then and now

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Cody Kasch - Desperate Housewives then and now

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Shawn Pyfrom - Desperate Housewives then and now

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Kyle MacLachian - Desperate Housewives then and now

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Alfre Woodard - Desperate Housewives then and now

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Neal McDonough - Desperate Housewives then and now

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Drea de Matteo - Desperate Housewives then and now

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Kevin Rahm - Desperate Housewives then and now

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Tuc Watkins - Desperate Housewives then and now

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Maiara Walsh - Desperate Housewives then and now

Ron Tom/Walt Disney Television via Getty Images, Michael Tullberg/Getty Images

Charles Mesure - Desperate Housewives then and now

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Jonathan Cake - Desperate Housewives then and now

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Madison De La Garza - Desperate Housewives then and now

Ron Tom/Walt Disney Television via Getty Images, Paul Archuleta/FilmMagic

If you're inspired to revisit Wisteria Lane, the entire series is available to stream on Hulu. 

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