The 43-year-old actress and wife of Antonio Banderas has entered rehab at the Marina Del Rey, California, based Daniel Freeman Hospital.
In a statement, Griffith says "My doctor has referred me to the Daniel Freeman Hospital to step down from the prescribed medication that I have been taking for a neck injury.
"I appreciate everyone's concern and I am sure that you will respect my and my family's privacy. With love, Melanie."
This isn't the first time the buxom blond star has headed in for treatment. In 1988, Griffith came to terms with an addiction to alcohol and cocaine while she was making Working Girl--a film that later earned her a Golden Globe and pushed her to big-screen stardom.
Soon after filming Working Girl, she entered Hazelden Center in Minnesota, a celeb-friendly clinic that also has treated the likes of Matthew Perry and Chris Farley. At the time, Griffith told Vanity Fair that, when she wrapped Working Girl, she just felt crummy. "I knew I had to change," she said. "I mean, everything."
Griffith, born into the Hollywood family of actress Tippi Hedren and actor Peter Griffith, has appeared in some 50 films. She married childhood sweetheart Don Johnson in 1976, divorced a year later, and then married him a second time in 1989, before divorcing again.
These days, Griffith is the freshly tattooed wife of Banderas, and she's recently starred in Banderas' Crazy in Alabama and John Waters' twisted satire Cecil B. Demented.