The True Blood star looks dashing in red at the HBO panel. Wonder if that color is going to attract more vampires?
We can only imagine how the Supernatural fans were hanging on every word out the star's mouth.
If Jensen's smiling at an audience member, safe to say that person's day has been made.
The Chuck star channels his inner über-Nerd at the SyFy/E! bash Saturday night at the Con (and he's got the hat and T-shirt to prove it!).
Click through the gallery to see who else made the scene, or cruise our Comic-Con index page to catch up on all the groovy goings-on in San Diego.
Jess hits the festivities looking like she's ready to soak up some of that San Diego sun.
The star of The Amazing Spider-Man got into the swing of things right away, delighting fans in Hall H by pretending to be a regular superhero fanatic with a question before removing his mask and thanking the audience for sharing in the coolest thing that's ever happened to him.
Kate, and her amazing legs, make a grand entrance at the Underwold panel at Comic-Con.
These Irish eyes are definitely smiling at the Fright Night panel.
Their movie may be spooky but the cast of The Raven look like the epitome of a friendly good time.
The Big Bang star is the picture of adorable as she took questions from fans.
This True Blood star has no problem being out in the daylight hours soaking up the San Diego sun.
Her job in the movie Drive may have been to fall in love with Ryan Gosling, but we can't help fall in love with Carey as she takes time to mingle with fans.
A Comic-Con favorite makes the day complete for fans at the pop-culture event.
The Dexter star seems to be having a great time in San Diego as he discusses the newest season of his hit show.
Star of Showtime's Shameless, the actress flashes her gorgeous smile for the fans during an opening-day panel.
Starring in director Ridley Scott's Prometheus alongside Michael Fassbender, the Oscar winner chats up the fans eager for more info on the flick.
Two movie-making heavyweights. One convention. The amount of talent in the room is astounding as two meet up to talk about their latest flick, The Adventures of Tintin.
The Comic-Con queen returns to her old stomping grounds to promote her new series, Ringer. Get the scoop!
The actor picks up a bottle of Connected Kenneth Cole Reaction fragrance at the Arts & Cinema Centre Presented by Nintendo.
The Conan the Barbarian star shows up to the Game of Thrones panel in his signature smoldering Khal Drogo eye makeup. Call us Khal Drool-go.
While Game of Thrones' Daenerys is silvery blond, the actress has gone brunette here. That or maybe her hair has been darkened by baby dragon fire?
Is Cersei in disguise? Like her Game of Thrones costar Emilia, the actress rocks a brunette shade.
Edward and Bella get cozy down in San Diego...but what is she smirking at? Could it be Rob's hair?
The three stars come together for the fans to discuss all the blood-sucking, werewolf-fighting action of Breaking Dawn Part 1. Oh yeah, and there's that vampire birth. Sure that came up too.