On the season premiere of season eight, Michelle Obama is the special guest at a fundraising event for When We All Vote. Later on in the episode, she accepts an invitation to go to Dre and Bow's house for dinner.
On "Daddy's Day," When Dre meets Resheida (Zendaya), a friend of Zoey's who doesn't have a Dad, the pair develop a bond after he is subbed by Zoey, and Resheida backs him up on the fact that Dads should be respected.
During the season one finale, "Pops' Pops' Pops," Mary J. Blige played a singer at the Savoy Ballroom, where she performed her hit "I'm Going Down."
Beginning in season one, Raven Symoné guest stars as Dre's sister Rhonda.
Sean "Diddy" Combs appeared in the season one finale alongside Blige, as Savoy, the owner of the Savoy club where the Johnson ancestors all met.
In season six episode "You Don't Know Jack," Joel McHale guest starred as a version of himself.
In "Plus Two Isn't a Thing," Tyra Banks, who is a lifelong friend of show creator Kenya Barris, according to People, played Dre's childhood friend who grew up to be an international pop star.
In "Jacked O'Lantern," Michael Strahan guest starred as Dre's cousin, June Bug.
During the season 6 finale, Persia White, Golden Brooks and Jill Marie Jones joined the episode to reunite with their former cast mate, Tracee Ellis Ross. In the episodes, Bow invites her "girlfriends" to join her feminist group.
In season 4, Dre hires Aloe Blacc for an ad campaign to bring back Juneteenth, a celebration of the end of slavery, to schools.