Amy Schumer
Ever one to keep it real, Amy Schumer was very literal as she listed off who she was wearing—with a side of TMI—to Giuliana Rancic at the 2016 Emmys: "Vivienne Westwood, Tom Ford shoes and an o.b. tampon."
Lizzo
After telling Chris Evans to marry her via Twitter, Lizzo jokingly expressed her disappointment in him not attending the 2019 MTV Movie & TV Awards by telling E! she was going home and walking away mid-interview. Fortunately, the star wasn't gone for long. After being asked if Evans responded, the songstress quipped, "The f--k no, it's Chris Evans. He ain't respond. If he responded, I wouldn't be here right now. I'd be on my honeymoon."
Joan Rivers
The iconic host was never afraid to poke fun at herself, including the time she told viewers she was wearing "formal wear Depends" on the red carpet.
Lady Gaga
It's not every day Lady Gaga comes by on the red carpet while inside of an egg, but when that did happen at the 2011 Grammys, Ryan Seacrest was ready with a microphone.
Jennifer Lawrence
A surprise is always possible when Jennifer Lawrence is around the red carpet, including in 2014 when she not-so-subtly snuck up behind Taylor Swift while the songstress was being interviewed by Ryan Seacrest at the Golden Globes. Years later, the GIF has become a classic.
Bong Joon-ho
The Parasite director got a laugh out of his interpreter, Sharon Choi, when she had to tell Giuliana Rancic on his behalf, "It's very embarrassing to translate, but he said that, thanks to me, this campaign has been a smooth journey."
Hugh Jackman
In 2013, E!'s red carpet co-host Giuliana Rancic capped off her SAG Awards interview with Les Misérables nominee Hugh Jackman with a harmonious moment—quite literally—as the two took turns singing to each other before a finale "Goodbye" duet.
Joan Rivers
During Joan Rivers' time on the red carpet with E!, there was certainly never a dull moment, including this one.
Lil Uzi Vert
When Giuliana Rancic asked 2018 Best New Artist nominee Lil Uzi Vert what was next for him, he quickly got the Internet's attention with this simple answer: "Uh, waking up—eat some pop tarts." As she responded, "Favorite interview of the night."
Kelly Clarkson
The Grammy-winning songstress had a moment at the 2018 Golden Globes that she and fans won't forget: finally meeting her idol, Meryl Streep. As she finished her interview with E!'s Ryan Seacrest, Clarkson turned and was visibly stunned to find Streep standing there. "Can I meet you?" she asked the iconic actress while Seacrest helped her down the stairs. "I'm such a fan." Cue one of the most endearing introductions in E! red carpet history!
Sacha Baron Cohen
At the 2012 Oscars, E!'s red carpet host Ryan Seacrest suffered an unforgettable prank when Sacha Baron Cohen, who arrived dressed as Admiral General Aladeen from The Dictator, poured the faux "ashes" of Kim Jong-il onto the interviewer's tuxedo. A few years later, in 2016, Cohen quickly popped up to say hello during Seacrest's interview with Lady Gaga. "What's in your hands? Check his hands," Seacrest joked.
Jim Carrey
In 2017, the famed comedian quickly made headlines while talking to E! News as a guest at Harper's Bazaar's party celebrating Icons by Carine Roitfeld during New York Fashion Week. Carrey said he wanted to "find the most meaningless thing that I could come to and join and here I am." Carrey went on to declare "I don't believe in icons," "There is no me" and "We don't matter." The clip of him sharing his standout point of view has been viewed more than 5 million times since.
Cardi B
At her first Grammy Awards in 2018, Cardi B once against proved she was the queen of candid after she told E!'s Giuliana Rancic, "I feel nervous, overwhelmed, everything...I feel it all...Butterflies in my stomach and vagina." Just like that, an instantly unforgettable red carpet moment was born.