Niall Horan
The former boy bander played his guitar while belting out "Black and White."
Sofi Tukker
"From our house to yours," the duo began, "This is our song 'Purple Hat.'"
Maren Morris & Hozier
In her first performance since giving birth, the country superstar was joined by Hozier for their hit "Bones."
Hussain Al Jassmi
The Emirati superstar sang "Mohen Jedan" and "Bahebek Wahashtini."
Lang Lang & Gina Alice Redlinger
The duo beautifully played "Four Hands" on the piano.
Luis Fonsi
The singer performed "No Me Doy Por Vencido," which he said, "means basically I'll never give up."
Liam Payne
Before singing his new single "Midnight," the Brit offered words of encouragement. "For my own personal benefit, I'm trying to think of all the beautiful things that are coming out of it and staying positive," he said. "This is one of them. I really feel at the moment we're all being brought a lot closer together by this solidarity that we have to feel right now. I think it's important so everybody keep their heads up. I hope you're enjoying yourselves at home as much as you can. I hope me singing today brings some people some enjoyment."
Black Coffee & Delilah Montagu
Streaming in from South Africa, the duo performed "Drive."
Eason Chan
Performing from China, he strummed his guitar and he sang "I Have Nothing."
Lisa Mishra
She dedicated her song "Sajna Ve" to "all the lovers" who were away from each other.
Charlie Puth
"Wash your hands," the Grammy nominee reminded fans, "with anything you've got." He then launched into an inspiring version of his breakout hit, "See You Again."