The Simpsons
"The City of New York vs. Homer Simpson" was pulled from syndication after the September 11 terrorist attacks because portions of the episode were set at the World Trade Center. It's since returned to syndication.
The X-Files
Considered of the the best episodes of The X-Files, "Home," was pulled after is 1996 airdate because it featured incest and infanticide.
Family Guy
Family Guy's season eight episode "Partial Terms of Endearment" was pulled because it featured Lois becoming a surrogate for a friend. But when the friend dies, Lois debates aborting the embryo.
Mike & Molly
The CBS comedy had its 2013 finale pushed because it featured a plot about a tornado. It was postponed after a deadly tornado in Oklahoma.
Hannibal
A 2013 episode of Hannibal was shelved following the bombing of the Boston Marathon and school shooting in Sandy Hook. The episode featured Molly Shannon as a character who brainwashed kids to kill other children. It was eventually posted online.
Buffy the Vampire Slayer
Season three of Buffy had two episodes delayed until the summer. "Earshot," which featured Jonathan (played by Empire co-creator Danny Strong) take a gun up into a school clock tower and "Graduation Day Part Two," the season three finale, which featured the destruction of the high school. Both were delayed due to concerns over depicting school violence in the wake of the Columbine High School shooting.
Heathers
The TV remake of Heathers was plagued by postponements. Originally developed for TV Land, it went over to Paramount Network, but was held following the school shooting at Stoneman Douglas High School. Then the show was dropped entirely in June 2018 only to get an airdate of October 2018 and it was burned off over five nights with heavily edited content.
Mr. Robot
The season one finale of USA Network's Emmy-winning series was held following the shooting deaths of reporter Alison Parker and cameraman Adam Ward due to depiction of a workplace shooting. "The previously filmed season finale of Mr. Robot contains a graphic scene similar in nature to today's tragic events in Virginia," USA Network said in a statement on the day of the murders. "Out of respect to the victims, their families and colleagues, and our viewers, we are postponing tonight's episode. Our thoughts go out to all those affected during this difficult time."