RuPaul's Drag Race veteran Valentina plays Angel Dumont Schunard, a drag queen and street percussionist with a zest for life.
Rising star Kiersey Clemons, known for her work in Hearts Beat Loud and Dope, plays Joanne Jefferson, Maureen's girlfriend and an Ivy League-educated lawyer.
Fresh off a stint on Dancing With the Stars, singer-actress-dancer Tinashe takes on the role of Mimi Marquez, a dancer who battles addiction.
Brandon Victor Dixon, who was nominated for an Emmy for his role in Jesus Christ Superstar Live, will play Tom Collins, a computer scientist who returns to New York after getting expelled from MIT.
Vanessa Hudgens, who previously starred in Fox's Grease: Live, will play Maureen Johnson, an outgoing performance artist.
Newcomer Brennin Hunt appeared in one episode of Nashville and previously appeared on The X Factor, is playing Roger Davis, a struggling musician and Mark's roommate and best friend.
Grease: Live veteran, Dancing With the Stars winner and Hamilton grad Jordan Fisher is set to play Mark Cohen, an aspiring filmmaker. The character is also the show's narrator.
Singer Mario, who recurred on Empire, is playing Benjamin Coffin III, Mark and Roger's former roommate-turned-landlord. He's always after their rent.