The E! late-night talk show host went with a leopard costume while her guest and Will and Grace star Megan Mullally wore cat ears.
The longtime host explained the next day on GMA, she went out as Vamperina because her great-granddaughter told her to.
The host dazzled as the Queen of Hearts, exactly one year after fainting on the Halloween show.
The hosts explained on the show that their costumes were designed by kids, who were also on the show.