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Willam H. Macy is Frank, the Gallagher family patriarch. The Emmy winner has been with the series since its starts and the show's future seems to hinge on whether he wants to return. "I know there's another 10 years of stories, and I'd love to see them. But when I think about acting them my back starts to hurt a little bit. (Laughs.) I know I want to do another season or two, and after that we shall see," Macy told The Hollywood Reporter.
Emma Kenney has played Debbie Gallagher since the start of the Showtime series. Kenney also stars in The Conners, the spinoff of Roseanne, as Harris, Darlene's (Sara Gilbert) daughter.
Emmy Rossum will say goodbye to Fiona Gallagher, the character she's played on Shameless since the start in 2011.
Liam Gallagher is the youngest sibling in the family, and since the start of the show has been played by several different actors (babies, man). Christian Isaiah took over the role for season nine.
Steve Howey, who was famous for his work on Reba McEntire's self-titled sitcom, plays Kev Ball on the series. Kev is Veronica's husband and the Gallagher family's neighbor. Howey has been with the show since it started in 2011.
Shanola Hampton has played Veronica Fisher, the Gallagher family neighbor, since the show began in 2011.
Viewers first met Isidora Goreshter as Svetlana in season three. Goreshter appeared as a guest star originally and joined the main cast in season seven.
Ethan Cutkosky, whose other credits include Law & Order: SVU, has played Carl Gallagher on Shameless since the show began.
Jeremy Allen White, Philip "Lip" Gallagher, has been with Shameless since the start. His other credits include SVU and Amazon's Homecoming opposite Julia Roberts.
Cameron Monaghan, Ian Gallagher, exited Shameless during its ninth season. His other credits include Gotham, The Giver and Mercy Street.