William H. Macy as Frank
Willam H. Macy played Frank, the alcoholic, type-B Gallagher family patriarch, on all 11 seasons of Shameless. As of April 2021, the month the series ended, the actor has been nominated for an Emmy five times for his role.
Emmy Rossum as Fiona
Emmy Rossum played Fiona Gallagher from season one to season nine in 2019, two years before the series ended.
Christian Isaiah as Liam
Liam Gallagher is the youngest sibling in the family, and since the start of the show has been played by several different actors (babies, man). Christian Isaiah took over the role for season nine in 2018.
Ethan Cutkosky as Carl
Ethan Cutkosky, whose other credits include Law & Order: SVU, played troubled youth-turned-cop Carl Gallagher on Shameless for all 11 seasons of Shameless.
Jeremy Allen White as Lip
Jeremy Allen White played Philip "Lip" Gallagher for Shameless' entire run. The actor's razor sharp-witted but hot-headed character began a family of his own towards the later seasons and stepped up to assume the parental role among his siblings after Fiona left.
Life imitated art for White: He is a proud father of two children.
Cameron Monaghan as Ian
Cameron Monaghan, aka Ian Gallagher, exited Shameless during its ninth season but returned for the next one. The actor's other credits include Gotham, The Giver and Mercy Street.
Emma Kenney as Debbie
Emma Kenney played Debbie Gallagher on all 11 seasons of Shameless. She also stars in The Conners, the spinoff of Roseanne, as Harris, Darlene's (Sara Gilbert) daughter.
Steve Howey as Kevin
Steve Howey, who was famous for his work on Reba McEntire's self-titled sitcom, played Kev Ball on the series since its debut. Kev is Veronica's husband and the Gallagher family's neighbor.
Shanola Hampton as Veronica
Shanola Hampton played Veronica Fisher, the Gallagher family neighbor, on all 11 seasons of Shameless.
Isidora Goreshter as Svetlana
Viewers first met Isidora Goreshter as Svetlana in season three. She left the show in season eight.