Emmy Rossum (Fiona Gallagher)
The actress, who left after season 9, and Mr. Robot creator Sam Esmail have been married since 2017. The couple began dating in 2013 after she was cast in his first full-length film, Comet.
William H. Macy (Frank Gallagher)
William and actress Felicity Huffman have been married since 1997 and share two daughters, Sophia Grace and Georgia Grace.
Cameron Monaghan (Ian Gallagher)
The actor, who plays a gay man and leading LGBTQ activist on the Showtime series, and Disney Channel actress Peyton List, who acted alongside Monaghan in the 2018 film Anthem of a Teenage Prophet, sparked romance rumors in fall 2017 when they were photographed at Disneyland together. In early 2019, E! News exclusively reported the pair had called it quits. He was previously linked to Shameless co-star Ruby Modine.
Noel Fisher (Mickey Milkovich)
The actor, who plays Ian's longtime love on the show and tied the knot in season 10, has been married to actress Layla Alizada since 2017. The two starred together on the series Godiva's more than a decade earlier.
Shanola Hampton (Veronica "V" Fisher)
The actress has been married to producer Daren Dukes since 2000 and they have two children, daughter Cai MyAnna and son Daren O.C.
Ethan Cutkosky (Carl Gallagher)
The actor has been with girlfriend Brielle Barbusca for a few years.
Laura Slade Wiggins (Karen Jackson)
The actress, who played Lip's girlfriend and left the Showtimes series in season 3, married studio stuntman Kyle Weishaar in June 2018.