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Emmy Rossum (Fiona Gallagher)
The actress, who left after season 9, and Mr. Robot creator Sam Esmail have been married since 2017. The couple began dating in 2013 after she was cast in his first full-length film, Comet.
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William H. Macy (Frank Gallagher)
William and actress Felicity Huffman have been married since 1997 and share two daughters, Sophia Grace and Georgia Grace.
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Jeremy Allen White (Lip Gallagher)
The actor and his wife Addison Timlin, who starred together in the 2008 film Afterschool, welcomed their first child, a baby girl, in Oct. 2018. They are expecting their second child.
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Cameron Monaghan (Ian Gallagher)
The actor, who plays a gay man and leading LGBTQ activist on the Showtime series, and Disney Channel actress Peyton List, who acted alongside Monaghan in the 2018 film Anthem of a Teenage Prophet, sparked romance rumors in fall 2017 when they were photographed at Disneyland together. In early 2019, E! News exclusively reported the pair had called it quits. He was previously linked to Shameless co-star Ruby Modine.
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Noel Fisher (Mickey Milkovich)
The actor, who plays Ian's longtime love on the show and tied the knot in season 10, has been married to actress Layla Alizada since 2017. The two starred together on the series Godiva's more than a decade earlier.
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Steve Howey (Kevin "Kev" Ball)
The actor and wife Sarah Shahi wed in 2009 but split in the summer of 2020. They share eldest son William Wolf and a younger twin son and daughter, Violet Moon and Knox Blue.
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Shanola Hampton (Veronica "V" Fisher)
The actress has been married to producer Daren Dukes since 2000 and they have two children, daughter Cai MyAnna and son Daren O.C.
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Ethan Cutkosky (Carl Gallagher)
The actor has been with girlfriend Brielle Barbusca for a few years.
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Joan Cusack (Sheila Jackson)
The actress, who left after season 5, has been married to Richard Burke since 1996. The two share two adult sons, Dylan and Miles. (The four are pictured at the 2013 Creative Arts Emmys.)
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Laura Slade Wiggins (Karen Jackson)
The actress, who played Lip's girlfriend and left the Showtimes series in season 3, married studio stuntman Kyle Weishaar in June 2018.
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Richard Flood (Ford Kellogg)
The Irish actor, who played Fiona's boyfriend, and Italian actress Gabriella Pession have been married since 2016. They have one child, son Giulio.