Mary Tyler Moore passed away on Jan. 25, 2017. She was "in the company of friends and her loving husband of over 33 years, Dr. S. Robert Levine," the star's rep told E! News in a statement.
"A groundbreaking actress, producer, and passionate advocate for the Juvenile Diabetes Research Foundation, Mary will be remembered as a fearless visionary who turned the world on with her smile."
After working roughly a decade as an actress, Moore landed the role of Laura Petrie on The Dick Van Dyke Show alongside TV legend, Dick Van Dyke. The role proved to be her big break with five seasons, two Emmy Awards and a Golden Globe win.
In 1967, Moore hit the big screen alongside Julie Andrews as Miss Dorothy Brown, Millie's sidekick. The two actresses famously tap danced together in an elevator during one iconic scene in the movie musical.
The rising star later was cast opposite Elvis Presley in the 1969 musical drama, Change of Habit. It was her last film until 1980, when she appeared on the silver screen again in Ordinary People.
As the '70s approached, she and then-husband Grant Tinker pitched a sitcom to CBS that would become the iconic Mary Tyler Moore Show. As single gal Mary Richards, Moore successfully portrayed the life of an independent working woman for one of the first times in television history. While she would work in Hollywood for several more decades, she would always be revered for her seven seasons as Richards.
In its seven seasons, The Mary Tyler Moore Show garnered a record-setting 29 Emmy Awards, including four for the lead star.
In addition to garnering plenty of industry acclaim, Moore worked with some of Hollywood's most prominent funny ladies, including Betty White, Valerie Harper and Cloris Leachman.
The Mary Tyler Moore Show inspired several spin-off series for its main characters, including Valerie Harper who famously played Moore's on-screen BFF, Rhoda Morgenstern. The character continued for five more seasons on Rhoda, where Moore also made occasional appearances.
Off-screen, the ladies formed an equally endearing friendship and saw each other through life's hurdles, including Harper' terminal brain cancer diagnosis in 2013.
"I'm absolutely devastated by this news," Moore told E! News in a statement at the time. "Valerie has given so much joy, laughter and love to the world. I join her fans and send much love and positive thoughts to her and her family during this difficult time."
In 1980, she returned to the movies in Ordinary People as a mother struggling to cope with the death of her son. The emotionally gripping performance earned Moore her first and only Oscar nomination for Best Actress.
Behind the scenes, Moore was first married in 1955 to Richard Carleton Meeker. The couple eventually welcomed son Richard Jr., but divorced a few years later in 1961.
The following year, the actress said "I Do" to CBS executive Grant Tinker in 1962. Following the tragic death of her 24-year-old son from an accidental gunshot in 1980, the pair divorced a year later.
Then, in 1983, she married Dr. Robert Levine and the two remained a couple until Moore's death.
Moore continued to act well into her 70s, starring in TV movies and film and making cameo appearances on modern shows like That '70s Show, Hot in Cleveland and Lipstick Jungle.
Privately, Moore was plagued by health problems throughout her life, beginning in her 30s when she was diagnosed with diabetes. Later, she battled with alcoholism and, following her divorce from Tinker, sought treatment at the Betty Ford Center. In 2011, she elected to have a benign tumor removed from her brain. In her final years, Moore was reported to suffer from diabetes-related ailments and, according to friends and colleagues, began to lose her eyesight.
The icon is survived by her husband, legions of fans and a Hollywood legacy that will impact generations of women for decades to come.