Audiences and critics alike applauded the veteran actor for his portrayal of the former football star found not guilty of the 1994 murder of ex-wife Nicole Brown Simpson in 2016's The People v. O. J. Simpson: American Crime Story series.
The actress channeled the infamous foreign exchange student charged with the heinous murder of her roommate in Lifetime's Amanda Knox: Murder on Trial in Italy.
In addition to starring on Orange is the New Black, the talented starlet brought to life the harrowing story of one of the three women Ariel Castro famously held captive for 11 years.
A Ryan Murphy casting favorite, the actress received critical acclaim for her depiction of the famous prosecutor in FX's The People v. O. J. Simpson: American Crime Story.
When his fourth wife (played by Kaley Cuoco) disappears in Lifetime movie Drew Peterson: Untouchable, suspicion falls on Lowe's shifty character. Though the real life Drew Peterson was never charged in the disappearance of Stacey Peterson, he was sentenced to 38 years in prison for the murder of his third wife and is still behind bars.
The actor bore a spine-chillingly similar resemblance to the man convicted of killing his wife and their unborn son in 2004's TV movie titled The Perfect Husband: The Laci Peterson Story.
In 2014's Lizzie Borden Took an Ax, the actress starred as a young women of the same name tried and acquitted of the 1892 hatchet murders of her father and stepmother.
Long before her Empire days, the Golden Globe winner starred as the woman whose son in 2008 was kidnapped by his father and taken to South Korea in Taken from Me: The Tiffany Rubin Story.
Loosely based on the serial killer widely known as the BTK Strangler, BBC's The Fall tracks the Fifty Shades actor as the evasive criminal.
Prior to landing her breakout role on Melrose Place, the stunning actress portrayed the scandalous alleged lover of Joey Buttafuoco who shot and severely wounded his wife in 1993's Casualties of Love: The Long Island Lolita Story.
In the 2015 Lifetime flick Beautiful & Twisted, Lowe starred as the wealthy hotel heir who, along with his mother, were killed by Novack's stripper wife.
The actress struck a striking similarity to the woman convicted of stabbing and shooting ex Travis Alexander to death in 2013's made-for-TV film Jodi Arias: Dirty Little Secret.
Spelling took on the role of the real-life popular cheerleader left for dead by her classmate Bernadette Protti in 1994's TV movie, A Friend to Die For.
The actress took on the role of the infamous prostitution ring leader known widely as the "Hollywood Madame" in 2014's Call Me: The Rise and Fall of Heidi Fleiss.
In 1992, audiences were left on the edge of their seats as the actress portrayed the teen murdered by her best friends in CBS' A Killer Among Friends.
The actor stars as one of the murderous members in Charles Manson's "family" in 2004's Helter Skelter.