Amy Adams & Christina Bale
This duo has played partners in multiple films including American Hustle, Vice and The Fighter.
Bradley Cooper & Rachel McAdams
Whether he plays her dick of a boyfriend in Wedding Crashers or a celebrated military contracter looking for love in Aloha, this pair knows how to garner attention with their on-screen presence.
Anne Hathaway & Jake Gyllenhaal
Whether their characters' romances are a subplot (Brokeback Mountain) or the main story (Love and Other Drugs), this adorable duo shines in tear-jerking flicks.
Bradley Cooper & Jennifer Lawrence
What range! In the film Serena, the gorgeous stars portrayed newlyweds based in the '30s, opposite to their modern-day serendipitous meeting in Silver Linings Playbook.
Drew Barrymore & Adam Sandler
As if making the totally '80s totally adorable in The Wedding Singer wasn't enough, these goofball sweethearts gave us shiny, happy 50 First Dates. Mahalo!
Sandra Bullock & Keanu Reeves
Speed marked Oscar winner Sandy's leading-lady debut. She and Keanu reteamed 12 years later for the time-bending Lake House. As K would say, whoa.
Kate Winslet & Leonardo DiCaprio
After winning hearts in the weepy disaster flick Titanic, the awards-bait duo showed us what could have happened had both Rose and Jack survived the sinking ship in the tumultuous Revolutionary Road.
Kate Hudson & Matthew McConaughey
From fumbling romance (How to Lose a Guy in 10 Days) to finding treasure (Fool's Gold), Katie and Matty are like catalog models in love.
Julie Delpy & Ethan Hawke
These two defined smitten in the sweet Before Sunrise and brought gravity to the same situation nine years later in Before Sunset.
Julia Roberts & Richard Gere
From Pretty Woman to Runaway Bride, Roberts and Gere epitomize the romantic-comedy genre...and all its love-'em-or-hate-'em clichés.
Meg Ryan & Tom Hanks
America's then sweetheart and the everyman seemed to do best in rom-coms where they don't know they're in love with each other. Hence our pics of Sleepless in Seattle and You've Got Mail and not Joe vs. the Volcano.
See real-life romances in our Celeb Weddings We Can't Wait For gallery!