1/9
REX/Shutterstock, Pool BENAINOUS/DUCLOS/Gamma-Rapho via Getty Images
Lori Ann Allison
Depp was married to the makeup artist from 1983 to 1985.
2/9
FOX
Sherilyn Fenn
The Twin Peaks actress dated Depp in 1986 following her split from Prince.
3/9
Barry King/WireImage
Ellen Barkin
After several red carpet appearances in 1994, the two split following a brief romance.
4/9
SNAP/ZUMAPRESS.com
Juliette Lewis
The What's Eating Gilbert Grape co-stars reportedly dated while filming but split afterwards.
5/9
Vinnie Zuffante/Getty Images
Jennifer Grey
The Dirty Dancing actress was reportedly engaged to Depp in the '80s.
6/9
Ron Galella, Ltd./WireImage
Winona Ryder
The Edward Scissorhands co-stars became engaged in 1990 and split three years later.
7/9
Tammie Arroyo/Getty Images
Kate Moss
The fashionable couple was inseparable in the '90s but split after a four-year relationship.
8/9
Frazer Harrison/Getty Images
Vanessa Paradis
After 14 years together, and two children, the two split up in June 2012.
9/9
George Pimentel/WireImage
Amber Heard
The actors were married from 2015 and split over a year later after she filed for divorce in late May.