As if these poor people haven't suffered enough, they had to endure an actual plane crash. An. Actual. Plane. Crash. Meredith, Derek, Cristina, Arizona, Mark and Lexie are left stranded in the woods for four days. Before they are even rescued, Lexie dies after Mark confessed his love for her, and then Mark almost dies multiple times before finally succumbing to his injuries back in the hospital. Arizona's leg is amputated due to her injuries (and she blames Callie for losing it and Alex for making her take his spot on the plane), Derek's hand is crushed and takes multiple surgeries to finally get it back to normal, and Cristina has her worst case of PTSD yet.