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In this rom-com, Reese plays a single mom living in Los Angeles whose life takes an unexpected turn when she lets three young men move in with her.
A southern girl herself, Reese plays a New York City fashion designer—born and raised in Alabama—who must return home to reconcile her past.
The actress returns to the cartoon world (previously doing voice overs for The Simpsons in 1989) and lends her voice to "Ginormica," an unusually tall woman in the DreamWorks Animation 3D hit.
Reese received an Emmy nomination for her role of Type-A mother Madeline Martha Mackenzie in the critically acclaimed HBO miniseries.
Reese makes her film debut as Dani Trant in this coming of age drama about love, betrayal and family values.
Starring as Vanessa, who is a troubled teenager, Reese finds herself getting into trouble with the police as she attempts to escape an abusive home and a serial killer.
Jennifer (Reese) and her brother David (Tobey McGuire) find themselves trapped in an old 50s tv show and must learn to survive in a world very different from their own.
Reese stars alongside Sarah Michelle Gellar and her future (but now ex) husband Ryan Phillippe in this dramatic coming of age story as Annette, a young girl who struggles with her sexuality and falling for a boy she knows she shouldn't love.
The actress goes head to head with Matthew Broderick as Tracy Flick, a high school senior who will stop at nothing to become student body president, despite her high school teacher's ill wishes.
Playing the role of Evelyn Williams, the young actress stars in this horror flick as the wife of fictional serial killer Patrick Bateman.
In Reese's most iconic role to date, she stars as Elle Woods, an ambitious sorority girl turned Harvard Law student who proves that blondes aren't dumb and that anyone can get into Harvard Law. "What, like it's hard?"
The actress stars in this biographical drama as June Carter, the lover of famous guitarist and country crooner, Johnny Cash.
Traveling for holidays is difficult. Traveling to four different parent's houses is even harder, as Reese and Vince Vaughn prove in this Christmas comedy about family, divorce, and holiday drama.
Starring as jaded softball player Lisa, Reese navigates life through career difficulties, love triangles, and coming to terms with growing old.
The Academy Award winner plays Marlena, a circus performer and ring leader's wife who finds herself in trouble when she falls in love with the circus' veterinarian.
Reese stars as Lauren Scott, a product testing executive who falls for two men at the same time and must navigate the dating world while struggling to choose who she should be with.
The blonde beauty stars as Juniper, the complicated love interest of a fugitive named Mud in this action filled drama.
Portraying the mother of murder victim Stevie Branch, Reese stars as Pamela Hobbs in this crime drama based on a true story about satanic cults and murderous rituals.
Reese portrayed author Cheryl Strayed in this biographical drama, in which she embarks on a hiking journey of healing and self-discovery. The critically acclaimed role earned Reese her second Best Actress Oscar nomination.
Reese lends her voice to animated film Sing as Rosita the pig, a stay-at-home mom who dreams of being a pop star.