Manchester Arena also posted the following statement which gave clues into where the explosion occurred: "We can confirm there was an incident as people were leaving the Ariana Grande show last night. The incident took place outside the venue in a public space. Our thoughts and prayers go out to the victims."
Grande's rep confirmed to E! News that the singer is currently "okay" and her team is "further investigating what happened."
Large numbers of concert goers began tweeting about a loud noise heard in the middle of the show, prompting the area to be evacuated.
Local police were quickly called to the scene and asked that people steer clear of the entire area to ensure their safety.
"Emergency services are currently responding to reports of an explosion at Manchester Arena. There are a number of confirmed fatalities and others injured. Please avoid the area as first responders work tirelessly at the scene," the Greater Manchester Police Department wrote on their official Facebook page.
Ivo Delgado, one of the many who was in attendance at the show tonight, told NBC News that the concert had just ended when he "heard a loud bang."
He added, "People started screaming and going to the other side of the arena."
Our thoughts go out to those who were involved in this tragedy.