Heather Locklear, Charlie Sheen

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Heather Locklear has Charlie Sheen in her thoughts.

The actress took to Instagram tonight to share her support for the actor and longtime friend, who is appearing for a live, in-studio interview with Today's Matt Lauer in Studio 1A Tuesday. A press release issued Monday said the 50-year-old actor "will make a revealing personal announcement."

"My heart hurts. Prayers for Charlie and his family," Locklear wrote with a photo of the pair together.

Her post comes after E! News learned from multiple sources that Sheen is HIV-positive. Reps for Sheen did not respond to E! News' request for comment.

The troubled actor has five children, ranging in age from 6 to 30, in addition to three ex-wives: Donna Peele (1995-1996), Denise Richards (2002-2006) and Brooke Mueller (2008-2011). E! News has learned that both Richards and her two daughters with Sheen, Sam and Lola, are HIV-negative.

Sheen, who has had his fair share of troubles in the past, has stayed away from the spotlight in the last year, with his last regular TV appearance being back in 2014 for FX's Anger Management.

The actor has openly dated multiple porn stars over the years, and has discussed his struggles with drug and alcohol addictions. During a videotaped deposition as part of Hollywood madam Heidi Fleiss's tax-evasion trial in 1995, for example, he admitted that he had spent $53,000 for "sexual services" from prostitutes over a 15-month period between 1991 and 1993.

And although he hasn't been involved in any projects, Sheen still made headlines when he trashed Richards on Twitter, suffered a bout of severe food poisoning and considered a run for public office.

To learn more about HIV/AIDS and to contribute in the fight against the diseases, visit amfAR.

(E! and NBC are both members of the NBCUniversal family.)

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